Dr. Lu Jianxi

Lu JianxiEDUCATION

1983 07 : Doctor of Medecine, Fourth Military Medical Unversity – Xi’An, China
1989 09 : Orthopedic specialist, Second Military Medical University – Shanghai, China
1994 09 : Master degree, Paris Diderot University (Paris VII) – Paris, France
1997 10 : Doctor of science, Paris Diderot University (Paris VII) – Paris, France
97-2000 : Post-doc, Mediaterranee University – Marseille, France
1999 10 : Certificate of advanced specialised training, Marseille Faculty of Medecine – Marseille, France
2000 11 : Habilitation à Diriger des Recherches (Accreditation to supervise research), Mediaterranee University – Marseille, France

INTERNSHIP AND RESIDENCY

1983-1989 Resident, Orthopedic and traumatology department, Changzhen hospital – Shanghai, China
                  Assistant, Second Military Medical University – Shanghai, China
1989-1992 Attending surgeon, Orthopedic department, Changzhen hospital – Shanghai, China
                  Senior lecturer, Second Military Medical University – Shanghai, China
1992-1994 Intern, Orthopedic and traumatology department, Saint-Louis hospital – Paris, France
1994-1997 Intern, Orthopedic and spinal surgery department, Institut Calot – Berck-sur-Mer, France
1998-2000 Resident, Orthopedic and traumatology department, Nord hospital – Marseille, France
2000-2001 Resident, Paediatric surgery department, Nord hospital – Marseille, France
2001-2010 CEO, BIOCETIS – Berck-sur-Mer and Cournonsec, France
2004-            CEO, Shanghai Bio-lu Biomaterials Co., Ltd. – Shanghai, China
2010-2012 R&D Director, BIOCETIS – Berck-sur-Mer and Cournonsec, France

RESEARCH

1986-1992 « Use of Chitin and Chitosan in surgery », Institute of Orthopedic surgery, Second Military Medical University (Shanghai) – Director: Pr Chun-Ling HOU
1992-1994 « Effect of chitosan on articular cartilage », Laboratory of orthopedic research, Lariboisière Saint-Louis Faculty of Medecine (Paris) – Director: Pr L. SEDEL
1994-1997 « Bone regeneration and porous bioceramics », Research Institute for Skeletal Diseases – IRMS (Berck sur Mer) – Director: Dr P. HARDOUIN
1997-2000 « Biocompability and biofonctionnality of bone cements », Laboratory of Extracellular Matrix/Biomaterials Interface, Faculty of Dentistry (Marseille) – Director: Pr J-P. PROUST
2000-2006 « Precilincal medicine studies on cartilage tissue engineering », Precilincal medicine research center, Academy of Military Medical Science (Beijing)
2001-2006 « Development of hybrid biomaterials», Research Institute for biomaterials and biotechnologies – IR2B (Berck sur Mer) – Director: Pr P. HARDOUIN
2003-            « Bioreactors and bone tissue engineering», Shanghai Jiaotong University – 9th People Hospital (Shanghai)
2004-            « Research and development of bioceramics», Shanghai Institute of Ceramics (Shanghai)

HONORARY TITLES

Member of the “Interdisciplinary Research Group on Injectable Osteo-articulary Biomaterials” (GRIBOI)
Member of “Nord Pas-de-Calais Federation of Biomaterials”
Member of “New York Academy of Science”
Visiting Professor, Biomedical Research Institute – Beijing, China
Visiting Professor, Academy of Military Medical Science, – Beijing, China
Visiting Professor, Littoral Cote d’Opal University – Boulogne, France
Adjunct Professor, Shanghai Jiaotong University – 9th People Hospital – Shanghai, China
Visiting Professor, Shanghai Institute of Ceramics – Shanghai, China
Associate researcher, IR2B, Littoral Côte d’Opale University – Berck-sur-Mer, France
Associate researcher, Institute for Medical Implants, Second Military Medical University – Shanghai, China
Organiser, “1st Franco-Chinese Congres of Odonto-Stomalogy”, October 2000 – Shanghai, China
Assistant secratary, “11th Interdisciplinary research conference on biomaterials”, March 2001 – Calais, France
Maître ès Medical Science, appointed by the Ministry of National Education, May 2001
Treasurer, “12th Interdisciplinary Research Conference on Biomaterials”, March 2002 – Shanghai, China
Member, Scientific Council of GRIBOI

PUBLICATIONS

1. Lu JX, Anselme K, Flautre B, Gallur A, Descamps M, Richart O, Thierry B, Hardouin P: Evaluation in vitro de la biocompatibilité de deux biocéramiques de porosité identique à base d’hydroxyapatite ou de phosphate tricalcique bêta. Actualités en Biomatériaux. 6: 137-46; 1997.
2. Lu JX, Flautre B, Anselme K, Gallur A, Descamps M, Thierry B, Hardouin P: Study of porous interconnections of bioceramic on cellular rehabitation in vitro and in vivo. Bioceramics. 10: 583-6; 1997.
3. Lu JX, Legrand O, Flautre B, Gallur A, Descamps M, Thierry B, Hardouin P, Sutter B: Reliability of dual energy x-ray absorptiometry in evaluation of phospho-calcic bioceramics in rabbit. Bioceramics. 10: 387-90; 1997.
4. Gallur A, Descamps M, Richart O, Thierry B, Anselme K, Lu JX, Flautre B, Hardouin P: Le naphtalène : agent porogène pour l’élaboration de substituts osseux en hydroxyapatite et phosphate tricalcique bêta. Actualités en Biomatériaux. 6: 127-35; 1997.
5. Richart O, Gallur A, Descamps M, Thierry B, Anselme K, Lu JX, Flautre B, Hardouin P: Techniques d’élaboration de substituts osseux en hydroxyapatite. Nouvelle voie d’élaboration : le coulage en bande. Actualités en Biomatériaux. 6: 285–93; 1997.
6. Penel G, Leroy G, Lu JX, Hardouin P, Gallur A, Richart O, Descamps M, Brès E: Apport de la microspectrométrie Raman à l’étude de la colonisation d’implant osseux de -TCP. Innov Techn Biol Med. 18:145-50; 1997.
7. Lu JX, Flautre B, Hardouin P: Réparation osseuse: comparaison entre os cortical et os spongieux (étude expérimentale chez le lapin et le mouton). Rev Rhum [Engl Ed]. 65: 685; 1998.
8. Lu JX, Gallur A, Anselme K, Flautre B, Descamps M, Thierry, Hardouin P: Comparative study of tissue reactions to calcium phosphate ceramics among cancellous, cortical, and medullar bone sites in rabbits. J Biomed Mater Res. 42: 357-67; 1998.
9. Lu JX, Flautre B, Anselme K, Gallur A, Descamps M, Thierry B, Hardouin P: Role of interconnections in porous bioceramics on bone recolonization in vitro and in vivo. J Mater Sci: Mater Med. 10: 111-20; 1999.
10. Lu JX, About I, Stephan G, Van Landuyt P, Déjou J, Fiocchi M, Lemaître J, Proust J-P: Histological and biomecanical studies of two bone colonizable cements in rabbits. Bone. 25: 41S-45S; 1999.
11. Lu JX, Meunier A, Sedel L, Guillemin G: Effect of chitosan to articular cartilage in the rat knees. Biomaterials. 20: 1937-44; 1999.
12. Flautre B, Anselme K, Delecourt C, Lu JX, Descamps M, Hardouin P: Histological aspects in bone regeneration of an association with porous hydroxyapatite and bone marrow cells. J Mater Sci: Mater Med. 10: 811-4, 1999.
13. Lu JX, Meunier A, Sedel L, Guillemin G: L’effet du chitosan sur cartilage articulaire chez le lapin. Actualités en Biomatériaux. 7: 145-50; 2000.
14. Lu JX, Descamps M, Dejou J, Koubi G, Hardouin P, Lemaitre J Proust J: The biodegradation mechanism of calcium phosphate biomaterials in bone. J Biomed Mater Res. 62: 408-12; 2002.
15. Lu JX, Huang ZW, Tropiano P, Clouet d’Orval B, Remusat M, Dejou J, Proust J-P, Poitout D: Human biological reactions at the interface between bone tissue and polymethylmethacrylate cement. J Mater Sci: Mater Med. 13: 803-9; 2002.
16. Jianxi Lu, Marie-Claude BLARY, Sébastien VAVASSEUR, Michel DESCAMPS, Karine ANSELME, Pierre HARDOUIN: Relationship between bioceramics sintering and micro-particles -induced cellular damages. J Mater Sci: Mater Med. 15: 359-63; 2004.
17. Ximin Guo, Changyong Wang, Yufu Zhang, Renyun Xia, Min Hu, Cuimi Duan, Qiang Zhao, Lingzhi Dong, Jianxi Lu, Ying Qing Song: Repair of Large articular cartilage defects with implants of autologous mesenchymal stem cells seeded into -tricalcium phosphate in a sheep model. Tissue Eng. 10 (11-12): 1818-29; 2004.
18. Ximin Guo, Changyong Wang, Cuimi Duan, Michel Descamps, Qiang Zhao, Lingzhi Dong, Shuanghong Lü, Karine Anselme, Jianxi Lu, Ying Qing Song : Repair of osteochondral defects with autologous chondrocytes seeded onto bioceramic scaffold in sheep. Tissue Eng. 10(11-12): 1830-40; 2004.
19. Xie Y, Hardouin P, Zhu Z, Tang T, Dai K, Lu J.: Three-dimensional flow perfusion culture system for stem cell proliferation inside the critical-size beta-tricalcium phosphate scaffold. Tissue Eng. 12(12):3535-43; 2006.
20. Xie Y, Chopin D, Hardouin P, Lu J.: Clinical, radiological and histological study of the failure of cervical interbody fusions with bone substitutes. Eur Spine J. 15(8): 1196-203; 2006.
21. Xie Y, Chopin D, Morin C, Hardouin P, Zhu Z, Tang J, Lu J.: Evaluation of the osteogenesis and biodegradation of porous biphasic ceramic in the human spine. Biomaterials. 27(13):2761-7; 2006.
22. Tang TT, Lu B, Yue B, Xie XH, Xie YZ, Dai KR, Lu JX, Lou JR.: Treatment of osteonecrosis of the femoral head with hBMP-2-gene-modified tissue-engineered bone in goats. J Bone Joint Surg Br. 89(1):127-9; 2007.
23. Zhang F, Chang J, Lu J, Lin K, Ning C.: Bioinspired structure of bioceramics for bone regeneration in load-bearing sites. Acta Biomater. 3(6):896-904; 2007.
24. M. Descamps, T. Duhoo, F. Monchau, J. Lu, P. Hardouin, J.C. Hornez, A. Leriche: Manufacture of macroporous -tricalcium phosphate bioceramics. J. Eur. Ceram. Soc. 11(28): 149-157, 2008.
25. Zhang F, Chang J, Lin K, Lu J.: Preparation, mechanical properties and in vitro degradability of wollastonite/tricalcium phosphate macroporous scaffolds from nanocomposite powders. J Mater Sci Mater Med. 19(1):167-73; 2008.
26. Xu S, Lin K, Wang Z, Chang J, Wang L, Lu J, Ning C.: Reconstruction of calvarial defect of rabbits using porous calcium silicate bioactive ceramics. Biomaterials. 29(17): 2588-96; 2008.
27. Faming Zhang, Kaili Lin, Jiang Chang, Jianxi Lu, Congqin Ning: Spark plasma sintering of macroporous calcium phosphate scaffolds from nanocrystalline powders. J Eur Ceram Soc. 3(28): 539-545; 2008.
28. Gan Y, Dai K, Zhang P, Tang T, Zhu Z, Lu J.:The clinical use of enriched bone marrow stem cells combined with porous beta-tricalcium phosphate in posterior spinal fusion. Biomaterials. 29(29): 3973-3982; 2008.
29. Li D, Tang T, Lu J, Dai K. :Effects of flow shear stress and mass transport on the construction of a large-scale tissue-engineered bone in a perfusion bioreactor. Tissue Eng Part A. 15(10):2773-83; 2009.
30. Wang C, Wang Z, Li A, Bai F, Lu J, Xu S, Li D.:Repair of segmental bone-defect of goat’s tibia using a dynamic perfusion culture tissue engineering bone. J Biomed Mater Res A. 92(3):1145-53; 2010.
31. Bai F, Wang Z, Lu J, Liu J, Lv R, Chen G, Wang J, Lin K, Zhang J, Huang X.:The Correlation between the Internal Structure and Vascularization of Controllable Porous Bioceramic materials in Vivo: A Quantitative Study. Tissue Eng Part A. 16(12): 3791-803; 2010.
32. Kaili Lin, Wei Yuan, Lu Wang, Jianxi Lu, Lei Chen, Zhen Wang2, Jiang Chang:Evaluation of Host Inflammatory Responses of β-tricalcium Phosphate Bioceramics Caused by Calcium Pyrophosphate Impurity using a Subcutaneous Model.J Biomed Mater Res. 99(20): 350-8; 2011.
33. Kaili Lin, Lei Chen, Haiyun Qu, Jianxi Lu, Jiang Chang: Improvement of mechanical properties of macroporous b-tricalcium phosphate bioceramic scaffolds with uniform and interconnected pore structures. Ceramics International. 37(7): 2397-403; 2011.
34. Chen D, Shen H, Shao J, Jiang Y, Lu J, He Y, Huang C.: Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. Int J Mol Med. 27(5):707-13; 2011.
35. Chen D, Shen H, Shao J, Jiang Y, Lu J, He Y, Huang C.: Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. Int J Mol Med. 27(5):707-13; 2011.
36. Chen D, Zhang X, He Y, Lu J, Shen H, Jiang Y, Zhang C, Zeng B. Co-culturing mesenchymal stem cells from bone marrow and periosteum enhances osteogenesis and neovascularization of tissue-engineered bone. J Tissue Eng Regen Med. 2011 Nov 9. doi: 10.1002/term.489. [Epub ahead of print]
37. Feng B, Jinkang Z, Zhen W, Jianxi L, Jiang C, Jian L, Guolin M, Xin D. The effect of pore size on tissue ingrowth and neovascularization in porous bioceramics of controlled architecture in vivo. Biomed Mater. 2011 Feb;6(1):015007. Epub 2011 Jan 5.
38. Wang, Chen; Xue, Yang; Lin, Kaili; Lu, Jianxi; Chang, Jiang; Sun, Jiao: The enhancement of bone regeneration by a combination of osteoconductivity and osteostimulation using β-CaSiO3/β-Ca3(PO4)2 composite bioceramics. Acta Biomaterialia, 8(1): 350-60;2012.
39. Chen D, Shen H, Shao J, Jiang Y, Lu J, He Y, Huang C:Superior mineralization and neovascularization capacity of adult human metaphyseal periosteum-derived cells for skeletal tissue engineering applications. Int J Mol Med. 2011 May;27(5):707-13.
40. Chen D, Zhang X, He Y, Lu J, Shen H, Jiang Y, Zhang C, Zeng B.:Co-culturing mesenchymal stem cells from bone marrow and periosteum enhances osteogenesis and neovascularization of tissue-engineered bone. J Tissue Eng Regen Med. 2011 Nov 9. doi: 10.1002/term.489. [Epub ahead of print]
41. Feng B, Jinkang Z, Zhen W, Jianxi L, Jiang C, Jian L, Guolin M, Xin D. The effect of pore size on tissue ingrowth and neovascularization in porous bioceramics of controlled architecture in vivo. Biomed Mater.; 6(1):015007, 2011.
42. Lin K, Yuan W, Wang L, Lu J, Chen L, Wang Z, Chang J. Evaluation of host inflammatory responses of β-tricalcium phosphate bioceramics caused by calcium pyrophosphate impurity using a subcutaneous model. J Biomed Mater Res B Appl Biomater. 99(2):350-8;2011.
43. Wang, Chen; Xue, Yang; Lin, Kaili; Lu, Jianxi; Chang, Jiang; Sun, Jiao: The enhancement of bone regeneration by a combination of osteoconductivity and osteostimulation using β-CaSiO3/β-Ca3(PO4)2 composite bioceramics. Acta Biomaterialia, 8(1): 350-60;2012.
44. Chen D, Zhang X, He Y, Lu J, Shen H, Jiang Y, Zhang C, Zeng B. Co-culturing mesenchymal stem cells from bone marrow and periosteum enhances osteogenesis and neovascularization of tissue-engineered bone. J Tissue Eng Regen Med. 6(10):822-32, 2012.
45. Jin F, Xie Y, Wang N, Qu X, Lu J, Hao Y, Dai K. Poor osteoinductive potential of subcutaneous bone cement-induced membranes for tissue engineered bone. Connect Tissue Res. 2013 Jun 12. [Epub ahead of print]
46. Wang Z, Guo Z, Bai H, Li J, Li X, Chen G, Lu J. Clinical evaluation of β-TCP in the treatment of lacunar bone defects: a prospective, randomized controlled study. Mater Sci Eng C Mater Biol Appl. 33(4):1894-9; 2013.
47. Liu S, Jin F, Lin K, Lu J, Sun J, Chang J, Dai K, Fan C. The effect of calcium silicate on in vitro physiochemical properties and in vivo osteogenesis, degradability and bioactivity of porous β-tricalcium phosphate bioceramics. Biomed Mater. 8(2):025008;2013.
48. Descamps M, Boilet L, Moreau G, Tricoteaux A, Lu J,Leriche A, Lardot V, Cambier F. Processing and properties of biphasic calcium phosphates bioceramics obtained by pressureless sintering and hot isostatic pressing. J. Eur. Ceram. Soc. 33 (7): 1263–70;2013.
49. Boilet L, Descamps M, Rguiti E, Tricoteaux A, Lu J, Petit F, Lardot V, Cambier F, Leriche A. Processing and properties of transparent hydroxyapatite and β tricalcium phosphate obtained by HIP process. Ceramics International. 39(1): 283–8; 2013.

STANDARDS COMMITTEE

1. YY/T 0683-2008 Surgical implants: β-tricalcium phosphate (Pharmaceutical industry standard)
2. YY/T 0511-2009 Evaluation of the biodegradation and osteoformation properties of porous bioceramics
3. YY/T xxxx-2013 Surgical implants: In-vitro evaluation of  hydroxyapatite implants

PATENTS

1. Patent FR2823305 (11.10.2002) et WO 02/081408 A1 (17.10.2002) : Method for controlling coalescence of particles forming a porous structure for example a bone implant
2. Chinese patents:

  • ZL 01253079.3
  • ZL 03116701.2
  • ZL 03116702.0
  • ZL 200410045451.3
  • ZL 200510025002.7
  • ZL 200610026058.9
  • ZL 200710047210.6
  • ZL 200910197369
  • CN 201110382573.1
  • ZL 201210486800.X
  • CN 201310029576.6